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Akademie věd České republiky - Požadavky

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Požadavky
Výběrová řízení - Akademie věd České republikyPhD XXXXXXX or Postdoctoral fellow Laboratory: LXXX – Laboratory of Tumor Immunology Position description We are looking for a qualified and motivated person with experience working in an immunology laboratory or a cell biology laboratory to work on a project: Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy: changing the paradigm Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo.Moreover,such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone of anti-IL-2 mAb.Complexes based on S4B6 mAb (IL-2/S4B6) stimulate predominantly CD122high populations,i.e.memory CD8+ T and NK cells,while those based on JES6-1A12 mAb (IL-2/JES6) stimulate selectively CD25+ cells,i.e.mostly Treg cells.Thus,the current paradigm in XXX XXXXX is that IL-X/SXBX are suitable for cancer immunotherapy and IL-X/JESX are predetermined for autoimmunities and transplantology.However,we found in preliminary experiments that IL-2/JES6 exert antitumor activity both per se and in combination with chemotherapy.Most promising antitumor effect of IL-2/JES6 was observed when injected after CTLA-4 plus PD-1 blockage using even highly suboptimal dosage of respective blocking mAbs.We thereby presume that IL-2/JES6 or their analogs like recombinantly produced immunocytokines may represent novel class of perspective cancer immunotherapeutics <.> XXX XXX of XXX project is to change the current paradigm in XXX XXXXX and show that complexes of IL-X and anti-IL-X mAb with selective stimulatory activity for CD25+ T cells possess antitumor activity and are promising tool for cancer immunotherapy particularly in combination with immune checkpoint inhibitors <.> Our group has established long-term collaboration XXXX XXX laboratory of XXXXX B.Spangler (John Hopkins University,Baltimore,USA) participating particularly...

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