Zpět

Akademie věd České republiky - Požadavky

Tento dokument byl načten z úřední desky, kterou vede Akademie věd České republiky.

Zasílat nové dokumenty emailem


Z důvodu ochrany osobních údajů nemůžeme dokumenty zobrazovat neregistrovaným uživatelům.

Požadavky
Výběrová řízení - Akademie věd České republikyPhD XXXXXXX or Postdoctoral fellow Laboratory: LXXX – Laboratory of Tumor Immunology Position description We are looking for a qualified and motivated person with experience working in an immunology laboratory or a cell biology laboratory to work on a project: Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy: changing the paradigm Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo.Moreover,such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone of anti-IL-2 mAb.Complexes based on S4B6 mAb (IL-2/S4B6) stimulate predominantly CD122high populations,i.e.memory CD8+ T and NK cells,while those based on JES6-1A12 mAb (IL-2/JES6) stimulate selectively CD25+ cells,i.e.mostly Treg cells.Thus,the current paradigm in XXX XXXXX is that IL-X/SXBX are suitable for cancer immunotherapy and IL-X/JESX are predetermined for autoimmunities and transplantology.However,we found in preliminary experiments that IL-2/JES6 exert antitumor activity both per se and in combination with chemotherapy.Most promising antitumor effect of IL-2/JES6 was observed when injected after CTLA-4 plus PD-1 blockage using even highly suboptimal dosage of respective blocking mAbs.We thereby presume that IL-2/JES6 or their analogs like recombinantly produced immunocytokines may represent novel class of perspective cancer immunotherapeutics <.> XXX XXX of XXX project is to change the current paradigm in XXX XXXXX and show that complexes of IL-X and anti-IL-X mAb with selective stimulatory activity for CD25+ T cells possess antitumor activity and are promising tool for cancer immunotherapy particularly in combination with immune checkpoint inhibitors <.> Our group has established long-term collaboration XXXX XXX laboratory of XXXXX B.Spangler (John Hopkins University,Baltimore,USA) participating particularly...

Načteno

edesky.cz/d/5337905

Meta

Nic nerozpoznáno


Z důvodu ochrany osobních údajů nemůžeme dokumenty zobrazovat neregistrovaným uživatelům.

Chcete vědět víc?

Další dokumenty od Akademie věd České republiky
18. 04. 2024
17. 04. 2024
16. 04. 2024
16. 04. 2024
16. 04. 2024
  ...a další
Více dokumentů od Akademie věd České republiky      Zasílat nové dokumenty emailem      Napište portálu edesky.cz