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Akademie věd České republiky - Požadavky

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Požadavky
Výběrová řízení - Akademie věd České republikyInstitute of Physiology of XXX XXXXX Academy of Sciences (IPHYS) is a leading research institute in XXX XXXXX of normal and pathological physiology.Main goal of XXX research is to characterize mechanisms of XXX development of serious human diseases,such as vascular and cerebrovascular events,ischemic heart disease,diabetes,hereditary metabolic disorders and neurodegenerative diseases.( http://www.fgu.cas.cz/en/ ) Glucose Homeostasis Unit of XXX Laboratory of Adipose Tissue Biology at IPHYS ( https://www.fgu.cas.cz/en/departments/biologie-tukove-tkane ) is studying physiological regulations of metabolism and their disturbances in obesity and associated diseases (i.e. metabolic syndrome).In order to help in XXX treatment of these disorders,we are exploring the effect of various diets,medications and natural substances. We are investigating the underlying mechanisms by combining experiments in mouse and cell models with clinical trials to apply new findings to clinical medicine <.> We are recruiting a highly motivated Postdoctoral researcher in XXX XXXXX of adipose tissue and liver pathophysiology XXX XXX of XXX proposed project is to elucidate the role of adipose tissue (mainly mesenteric fat depot) in XXX barrier function of XXX XXXXX intestine,including its microbiome,during diet-induced development of metabolic dysfunction-associated steatotic liver disease (MASLD) in mice of both sexes,and also to study how supplementation with omega-3 fatty acids (mainly through phospholipid-based products) affects the properties of this barrier.Your work will involve: 1) monitoring mice during dietary interventions and performing in vivo analyses including indirect calorimetry,DEXA and various tolerance tests,2) in vivo determination of intestinal permeability,3) studying adipose and liver tissue using multi-omic and other analyses,also using ex vivo experiments on adipose tissue explants and isolated hepatocytes,4) determining ch...

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